Is it normal to feel worse on sertraline?

Answered by Phillip Nicastro

It is normal to feel worse initially when starting sertraline, also known as Zoloft. This is because it takes time for the medication to build up in your system and start having a therapeutic effect. During this period, which can last several weeks, some individuals may experience an increase in symptoms or new side effects.

One reason for feeling worse on sertraline in the beginning is that the medication can initially disrupt the balance of chemicals in your brain. This can temporarily worsen your mood, increase anxiety, or cause other side effects such as nausea, dizziness, or fatigue. These effects are usually transient and tend to subside as your body adjusts to the medication.

Additionally, sertraline works by increasing the levels of serotonin in your brain, which is a neurotransmitter that plays a key role in regulating mood. However, it can take time for these increased serotonin levels to have a noticeable impact on your symptoms. In the meantime, you may still be experiencing the same depressive or anxious thoughts and feelings.

It’s important to note that everyone’s response to sertraline can vary. While some individuals may experience a temporary worsening of symptoms, others may not. It’s a good idea to discuss any concerns or changes in your symptoms with your healthcare provider, as they can provide guidance and support during this adjustment period.

It’s worth mentioning that feeling worse in the beginning does not necessarily mean that the medication won’t work for you. In fact, research has shown that sertraline can be effective in treating depression, anxiety disorders, and other conditions. It’s often recommended to give the medication a fair trial of at least 4-6 weeks to fully evaluate its effectiveness.

During this initial period, it’s important to practice self-care and have support in place. Engaging in activities that promote relaxation and well-being, such as exercise, spending time in nature, or practicing mindfulness, can be helpful. It can also be beneficial to reach out to friends, family, or a therapist for emotional support.

Remember, sertraline is not intended to change your personality, but rather to help alleviate symptoms of depression or anxiety so that you can feel more like yourself again. It’s a tool that can support your overall well-being, but it’s important to approach it with patience and realistic expectations.

Feeling worse initially when starting sertraline is a common experience. It may be due to the medication’s effects on brain chemistry and the time it takes for it to start working. Give yourself time to adjust, be patient, and communicate any concerns with your healthcare provider. With time and proper support, you may start to notice improvements in your symptoms and overall well-being.