What happens if you miss 2 days of Zoloft?

Answered by James Kissner

If you miss two days of Zoloft, also known as sertraline, it is possible that you may experience discontinuation symptoms. Discontinuation symptoms are a set of physical and psychological symptoms that can occur when you stop or miss doses of certain medications, including antidepressants.

Zoloft is an SSRI (selective serotonin reuptake inhibitor) commonly prescribed for the treatment of depression, anxiety disorders, and other mental health conditions. It works by increasing the levels of serotonin, a neurotransmitter that plays a role in regulating mood, in the brain.

When you abruptly stop or miss doses of Zoloft, it can disrupt the balance of serotonin in your brain, leading to discontinuation symptoms. These symptoms can vary in severity and duration from person to person, but they often include:

1. Flu-like symptoms: You may experience flu-like symptoms such as headache, dizziness, fatigue, and nausea.
2. Electric shock sensations: Some people describe feeling “brain zaps” or electric shock-like sensations in their head or throughout their body.
3. Rebound depression or anxiety: Discontinuation of Zoloft can cause a temporary worsening of depression or anxiety symptoms, which may include low mood, irritability, or increased anxiety.
4. Sleep disturbances: You may have trouble falling asleep or experience vivid dreams when discontinuing Zoloft.
5. Digestive issues: Some individuals may experience digestive symptoms like diarrhea, stomach cramps, or nausea.

To prevent or minimize discontinuation symptoms when missing doses of Zoloft, it is important to follow these steps:

1. Take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose. If that is the case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.
2. If you frequently forget to take your medication, consider using a pill organizer or setting reminders on your phone to help you remember.
3. Talk to your healthcare provider about the possibility of using a long-acting formulation of sertraline, such as an extended-release version, which may be less prone to causing discontinuation symptoms.
4. If you are planning to discontinue Zoloft or switch to a different medication, work closely with your healthcare provider to develop a tapering schedule. Gradually reducing the dose over time can help minimize the risk of discontinuation symptoms.

It is important to note that everyone’s experience with discontinuation symptoms can vary. Some individuals may have no symptoms at all, while others may experience more severe symptoms. If you do experience discontinuation symptoms, it is generally recommended to reach out to your healthcare provider for guidance and support.

Remember, this answer is not personalized medical advice, so it’s always best to consult with your healthcare provider for specific guidance regarding your medication regimen.