What drugs should you not take with cyclobenzaprine?

Answered by Willie Powers

It is important to avoid taking certain medications, known as MAO inhibitors, while you are being treated with cyclobenzaprine. These MAO inhibitors include isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine. Taking these medications together with cyclobenzaprine can lead to a potentially dangerous condition called serotonin syndrome.

Serotonin syndrome is a rare but serious reaction that can occur when there is an excessive amount of serotonin in the body. Symptoms of serotonin syndrome can range from mild to severe and may include agitation, confusion, rapid heartbeat, dilated pupils, high blood pressure, muscle rigidity or twitching, tremor, sweating, shivering, diarrhea, headache, and in severe cases, seizures or loss of consciousness.

To avoid the risk of serotonin syndrome, it is crucial to inform your healthcare provider about all the medications you are currently taking, including any over-the-counter drugs or herbal supplements. Your healthcare provider will be able to determine if it is safe for you to take cyclobenzaprine and can provide guidance on any necessary medication adjustments or alternatives.

In addition to MAO inhibitors, there may be other medications that can interact with cyclobenzaprine. It is always important to discuss all your medications with your healthcare provider to ensure safe and effective treatment. They may need to adjust the dose or monitor you closely for any potential interactions.

Remember, this information is not exhaustive, and it is always best to consult with your healthcare provider for personalized advice based on your specific medical history and current medications.